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Resveralip

29,90 €

Food supplement based on Liposomal Resveratrol.
Cardiovascular protective, neuroprotective.
PACKAGING : 30 stickpack of 1 g
USEFUL FOR
promote physiological antioxidant activity, the functionality of the cardiovascular system and microcirculation.
PLUS
• ready-to-use stick pack • maximum concentration of active ingredients • easy to take orosoluble sachets • high bioavailability • contains no sugars • no artificial colourings and flavourings • no ingredients of animal origin • gluten-free and lactose-free • with natural excipients
HOW TO USE
It is recommended to take one stickpack per day, as is. The product can be taken at any time of the day.
WARNINGS
Keep out of reach of children under three years. Do not exceed the recommended daily dose. Supplements are not intended as a substitute for a varied and balanced diet and a healthy lifestyle. Contains sweetener.

EAN: 8056045400130

Resveratrol is a naturally occurring molecule found in red grape skin, peanuts, blueberries and some other berries. It is a powerful antioxidant produced by plants in response to stress, injury, infection or ultraviolet (UV) radiation. These antioxidant properties give it an anti-aging action by counteracting the damage caused by free radicals and allowing it to combat premature aging of the body’s tissues.

Resveratrol is a powerful antioxidant that can also regulate the synthesis of antioxidant enzymes and therefore reduce the production of free radicals. Resveratrol is able to modulate a large number of cellular signaling pathways involved in the regulation of inflammatory processes, in the immune response to infections and stress and in tumor formation processes. Resveratrol is an anti-inflammatory, inhibits the proliferation of tumor cells, causes apoptosis (programmed cell death), reduces their ability to invade healthy tissue and the ability to form new blood vessels, necessary for tumor development. According to recent studies, Resveratrol could act on a key molecule in the energy regulation mechanisms of the cell, leading to the conversion of white adipose tissue into brown adipose tissue, with consequent reduction in body weight of treated animals.

Numerous studies have shown the ability of Resveratrol to increase the expression of Angiotensin 1-7 through the suppression of the ANG II/AT1R axis, through the enhancement of the Ang (1-7)/Mas axis and through the increase in plasma levels of the same Angiotensin 1-7. Resveratrol therefore acts, with its protective effect and its ability to counteract aging, on the Cardiovascular System and the Renal System, improving their functionality.

Resveratrol can inhibit some processes that lead to the development of cardiovascular diseases, protects vessels from plaque formation and the proliferation of smooth muscle tissue, stimulates the production of nitric oxide responsible for vasodilation processes and inhibits platelet activation and aggregation, the first step in the formation of clots that can cause heart attacks and strokes. Resveratrol has a protective action against neurodegenerative diseases. It stimulates neurogenesis and the formation of new vessels in the brain, stimulates the removal of the β-amyloid peptide, a constituent of the amyloid plaque, which accumulates in certain areas of the brain in subjects affected by Alzheimer’s disease, and reduces inflammatory processes and oxidative stress at the level of neurons.

Finally, some studies have demonstrated the importance of using Resveratrol as a chemoprotective, useful in resistance to chemotherapy. Some studies have shown that Resveratrol has reduced cardiac toxicity from Doxorubicin, decreasing cardiovascular risk, eliminating reactive oxygen species (ROS) and protecting tissues. In addition, Resveratrol has shown in some studies an increase in antitumor efficacy and has reduced the cardiotoxic and nephrotoxic effect of arsenic trioxide in hematological malignancies, activating antioxidant defense mechanisms.

Oncotarget. 2017 Aug 9. A comparative study of anti-aging properties and mechanism: resveratrol and caloric restriction. Li J, Zhang CX, Liu YM, Chen KL, Chen G. – Link

J Cosmet Laser Ther. 2019. Resveratrol as an active ingredient for cosmetic and dermatological applications: a review. Ratz-Łyko A, Arct J. – Link

Nutrients. 2019 May. Influence of Resveratrol on the Immune Response. Lucia Malaguarnera – Link

Antioxidants (Basel). 2018 Oct 20. Cytoprotective Effects of Natural Compounds against Oxidative Stress. Mehta J, Rayalam S, Wang X. – Link

Int J Clin Exp Pathol. 2014 Oct 15. Cardioprotective effect of resveratrol on atherogenic diet-fed rats. Meng C, Liu JL, Du AL. – Link

Aleksandra Rodacka, Joanna Strumillo, Mieczyslaw Puchala, Eligiusz Serafin, Grzegorz Bartosz “Comparison of protective properties of resveratrol and melatonin in the radiation inactivation and destruction of glyceraldehyde-3-phosphate dehydrogenase and lactate dehydrogenase” PubMed 2019 – Link

Amini, Saeedeh Jafari Nodooshan, Milad Ashrafizadeh, Seyed-Mohammad Eftekhari, Tayebeh Aryafar, Leila Khalafi, Ahmed Eleojo Musa, Seyed Rabie Mahdavi, Masoud Najafi, Bagher Farhood “Resveratrol Induces Apoptosis and Attenuates Proliferation of MCF-7 Cells in Combination with Radiation and Hyperthermia” PubMed, 2021 – Link

Endocr Relat Cancer. 2014 May 6. Resveratrol and cancer: focus on in vivo evidence. Carter LG, D’Orazio JA, Pearson KJ. – Link

Oncol Lett. 2020 Apr. Autophagy suppresses resveratrol-induced apoptosis in renal cell carcinoma 786-O cells. Yao H, Fan M, He X. – Link

Oncotarget. 2017 Mar 7. Resveratrol induces cell cycle arrest and apoptosis with docetaxel in prostate cancer cells via a p53/ p21WAF1/CIP1 and p27KIP1 pathway. Singh SK, Banerjee S, Acosta EP, Lillard JW, Singh R. – Link

Effects of resveratrol on human immune cell function. Falchetti R, Fuggetta MP, Lanzilli G, Tricarico M, Ravagnan G. Life Sci. 2001 Nov 21;70(1):81-96 – Link

In vitro antitumour activity of resveratrol in human melanoma cells sensitive or resistant to temozolomide. Fuggetta MP, D’Atri S, Lanzilli G, Tricarico M, Cannavò E, Zambruno G, Falchetti R, Ravagnan G. Melanoma Res. 2004 Jun;14(3):189-96 – Link

Effect of resveratrol on proliferation and telomerase activity of human colon cancer cells in vitro. Fuggetta MP, Lanzilli G, Tricarico M, Cottarelli A, Falchetti R, Ravagnan G, Bonmassar E. J Exp Clin Cancer Res. 2006 Jun;25(2):189-93 – Link

Resveratrol down-regulates the growth and telomerase activity of breast cancer cells in vitro. Lanzilli G, Fuggetta MP, Tricarico M, Cottarelli A, Serafino A, Falchetti R, Ravagnan G, Turriziani M, Adamo R, Franzese O, Bonmassar E. Int J Oncol. 2006 Mar;28(3):641-8 – Link

Int J Mol Sci. 2019 Feb 20. Resveratrol as a Tumor-Suppressive Nutraceutical Modulating Tumor Microenvironment and Malignant Behaviors of Cancer. Han Y1,2, Jo H3,4, Cho JH5, Dhanasekaran DN6, Song YS7,8,9 – Link

Molecules. 2019 Mar 21. Resveratrol Inhibits the Migration and Metastasis of MDA-MB- 231 Human Breast Cancer by Reversing TGF-β1-Induced Epithelial-Mesenchymal Transition. Sun Y, Zhou QM, Lu YY, Zhang H, Chen QL, Zhao M, Su SB – Link

Cancer Med. 2019 Mar. Resveratrol promotes sensitization to Doxorubicin by inhibiting epithelial-mesenchymal transition and modulating SIRT1/β-catenin signaling pathway in breast cancer. Jin X, Wei Y, Liu Y, Lu X, Ding F, Wang J, Yang S. – Link

Phytomedicine. 2019 Mar 1. Resveratrol mediated cancer cell apoptosis, and modulation of multidrug resistance proteins and metabolic enzymes. El-Readi MZ, Eid S, Abdelghany AA, Al-Amoudi HS, Efferth T, Wink MInt J Mol Sci. 2020 Mar 18. Potential Adverse Effects of Resveratrol: A Literature Review. Shaito A, Posadino AM, Younes N, Hasan H, Halabi S, Alhababi D, Al-Mohannadi A, Abdel-Rahman WM, Eid AH, Nasrallah G, Pintus G – Link

Dan-Dan Zhou 1, Min Luo 1, Si-Yu Huang 1, Adila Saimaiti 1, Ao Shang 1, Ren-You Gan 2 3, Hua-Bin Li 1 “Effects and Mechanisms of Resveratrol on Aging and Age-Related Diseases” PubMed 2021 – Link

Giulia Lanzilli, Andrea Cottarelli, Giuseppe Nicotera, Serena Guida, Giampiero Ravagnan, Maria Pia FuggettaAnti-inflammatory effect of resveratrol and polydatin by in vitro IL-17 modulation PuBMed, 2012 – Link

Prem Kumar, Anupam Bishayee, Kwang Seok Ahn “The Role of Resveratrol in Cancer Therapy” PubMed 2017 – Link

Samaneh Brenjian , Ashraf Moini , Nazila Yamini , Ladan Kashani , Maryam Faridmojtahedi, Mojdeh Bahramrezaie , Mahshad Khodarahmian , Fardin Amidi “Resveratrol treatment in patients with polycystic ovary syndrome decreased pro-inflammatory and endoplasmic reticulum stress markers” PubMed 2020 – Link

Seyed Hossein Shahcheraghi , Mahtab Zangui , Marzieh Lotfi , Majid Ghayour-Mobarhan , Ahmad Ghorbani , Hossein Zarei Jaliani , Hamid Reza Sadeghnia , Amirhossein Sahebkar ”Therapeutic Potential of Curcumin in the Treatment of Glioblastoma Multiforme” PubMed, 2019 – Link

Shannon Reagan-Shaw, Hasan Mukhtar, Nihal Ahmad “Resveratrol imparts photoprotection of normal cells and enhances the efficacy of radiation therapy in cancer cells” PubMed 2008 – Link

Shi-Jun Wang 1, Xing-Xiang Wang, Fang-Hua Fan “Inhibitory effect of resveratrol on cardiac fibroblast proliferation induced by angiotensin II” PubMed 2008

Soltan 1, Mansour Esmaili Dahej 1, Maryam Yadegari 2, Ali Moradi 3, Zeinab Hafizi Barjin 1, Fatemeh Safari 1 4 Resveratrol Confers Protection Against Ischemia/Reperfusion Injury by Increase of Angiotensin (1-7) Expression in a Rat Model of Myocardial Hypertrophy” PubMed 2021 – Link

POSSIBLE ASSOCIATIONS
Melatonina, Pea, Quercilip, Fito Brain Plus, Fito Anti-Aging
INGREDIENTS
Erythritol, Liposomal Resveratrol (coating agents: Sunflower Lecithin, Inulin, Phosphatidylcholine, Trehalose, Histidine), flavourings.

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