For example, the lymphocyte, a type of white blood cell belonging to the Immune System, can receive signals from both the Central Nervous System and the Endocrine System. PNEI research has also allowed us to identify the anatomical structures connected to life and those, instead, connected to death.

The path of Life is characterized by the Pineal Gland, the Endocannabinoid System and the ACE2-Angiotensin 1-7 System. PNEI has managed to identify in them the three bio-regenerative systems of the human body and to demonstrate that old age is nothing more than the progressive reduction of the functionality of these systems.

The Death Path is instead characterized by the Adeno-Hypophysis, the Opioid System and the ACE-Angiotensin 2 system. Angiotensin 2 causes hypertension, cardiac hypertrophy, thrombosis and fibrosis and stimulates tumor growth, while Angiotensin 1-7 promotes regeneration, having hypotensive, cardioprotective, antithrombotic and antitumor action.

According to recent advances in the PNEI area, the ACE2-Ang 1-7 axis cannot be investigated separately, since it is part of a systemic, anti-inflammatory and antitumor neuroendocrine system, which is essentially constituted by the same Ang 1-7, by the Pineal Gland, through its most known hormone, Melatonin (MLT), and by the Endocannabinoid System with Endocannabinoids and PEA. To understand the path to healing, it is essential to understand the mechanisms that lead an individual down the path to illness.

It is clear that the mind is to be understood as a reality that acts and operates on the body and that, vice versa, the body is equipped with autonomous chemical-physical mechanisms and properties that influence the mind.

The key point is that thanks to an active and well-functioning PNEI system, effective disease prevention is achieved. The psycho-emotional and affective state of a person influences and modifies the course of an illness. An individual can develop an illness due to an enormous variability of genetic and environmental factors that modify the balance of the PNEI. Factors such as having good psychological health, following a correct diet and having a strong immune system help in maintaining this balance. With the PNEI, a model of research and interpretation of health and illness is created that sees the human organism as a structured and interconnected unit, where the psychic and biological systems influence each other.

This provides the basis for proposing new integrated approaches to the prevention and treatment of the most common diseases, especially chronic ones, and at the same time, it configures the possibility of going beyond the historical opposition between medicine and psychology, which assigns the body to the former and the psyche to the latter. If the disorder involves the emotional sphere, there are also repercussions on a physical level. In fact, all psychic processes, whether they belong to the sphere of thought or that of feeling or will, produce real chemical processes in the organism and, therefore, the treatment is oriented towards phytotherapy combined with psychotherapy. If the disorder involves the body, the imbalance will lead to physical-anatomical alterations that can be documented at a diagnostic level and the treatment involves the administration of the same molecules of the human body that are missing or no longer functioning).