40,00 €
The synergy of substances that promote brain health improves cognitive functions and protects against brain degenerative forms. The FITO BRAIN PLUS formula, based on Boswellia, Ginko, PEA, Curcumin, Quercitin and Red Grapes, was created with the aim of promoting mental health and preventing various forms of neuronal degenerative disease.
Ginko-Biloba has the property of stimulating the blood microcirculation of the brain, improving its brain activity and has a neuroprotective action, significantly improving memory consolidation in both young and elderly subjects: in fact, it is often used against memory disorders and for conditions that, especially in old age, are associated with a reduction in blood flow to the brain (such as headaches, dizziness and vertigo, tinnitus, difficulty concentrating and mood disorders). It is also used in other problems associated with circulation disorders (such as leg pain while walking, typical of claudication, and Raynaud’s syndrome).
It is useful in the treatment of tinnitus and vertigo syndromes of vascular origin. Scientific evidence suggests that Ginkgo extract could be really effective in cases of anxiety, to improve mental performance, in cases of dementia, against vision problems associated with diabetes, against glaucoma, to combat premenstrual syndrome, against schizophrenia and dyskinesia.
Ginko, together with Red Grapes, has antioxidant properties and they act in synergy to improve cerebral blood microcirculation and therefore blood flow. Together they protect against oxidative stress. Vitis Vinifera has been used for thousands of years for its nutritional and medicinal properties and is traditionally used in the treatment of capillary bleeding, edema and inflammation. Red Vine is particularly appreciated for its antioxidant and vasoprotective properties, has also shown beneficial effects on memory and cognitive functions and contributes to brain health.
The Flavonoids and Anthocyanins present in Red Vine fight free radicals, protecting brain cells from oxidative stress, preventing cognitive deterioration and improving neuronal function.
PEA (Palmitoylethanolamide), the discovery of whose mechanism of action is due to Nobel Prize winner Prof. Levi-Montalcini, has an anti-inflammatory action on all brain connections and has cannabinergic effects. The structural analogy with the endocannabinoid molecule AEA (Anandamide) gives the lipid the ability to bind peripheral CB2 cannabinoid receptors, positively modulating the expression of these receptors. Curcumin, on the other hand, is able to cross the blood-brain barrier and is a powerful anti-inflammatory. Quercetin helps promote neurogenesis in the hippocampus area of the brain responsible for learning and memory function. Finally, Boswellic Acids have a strong anti-inflammatory action, acting with a mechanism similar to the NSAID drug, but without causing side effects, and are useful in the reabsorption of cerebral edema.
Diamond BJ, Bailey MR. Ginkgo biloba: indications, mechanisms, and safety. Psychiatr Clin North Am. 2013 Mar;36(1):73-83. doi: 10.1016/j.psc.2012.12.006. PMID: 23538078 – Link
Nassiri-Asl M, Hosseinzadeh H. Review of the Pharmacological Effects of Vitis vinifera (Grape) and its Bioactive Constituents: An Update. Phytother Res. 2016 Sep;30(9):1392- 403. doi: 10.1002/ptr.5644. Epub 2016 May 16. PMID: 27196869 – Link
Tabeshpour J, Mehri S, Shaebani Behbahani F, Hosseinzadeh H. Protective effects of Vitis vinifera (grapes) and one of its biologically active constituents, resveratrol, against natural and chemical toxicities: A comprehensive review. Phytother Res. 2018 Nov;32(11):2164- 2190. doi: 10.1002/ptr.6168. Epub 2018 Aug 8. PMID: 30088293 – Link
Qingwang Lian 1, Yongsheng Nie 1, Xiaoyou Zhang 2, Bo Tan 1, Hongying Cao 1, Wenling Chen 2, Weiming Gao 2, Jiayi Chen 1, Zhijian Liang 1, Huangling Lai 1, Siming Huang 1, Yifei Xu 1, Weiwen Jiang 1, Ping Huang 1 “Effects of grape seed proanthocyanidin on Alzheimer’s disease in vitro and in vivo” PubMed 2016 – Link
Colizzi M, Bortoletto R, Colli C, Bonomo E, Pagliaro D, Maso E, Di Gennaro G, Balestrieri M. Therapeutic effect of palmitoylethanolamide in cognitive decline: A systematic review and preliminary meta-analysis of preclinical and clinical evidence. Front Psychiatry. 2022 Oct 28;13:1038122. doi: 10.3389/fpsyt.2022.1038122. PMID: 36387000; PMCID: PMC9650099 – Link
Askarizadeh A, Barreto GE, Henney NC, Majeed M, Sahebkar A. Neuroprotection by curcumin: A review on brain delivery strategies. Int J Pharm. 2020 Jul 30;585:119476. doi: 10.1016/j.ijpharm.2020.119476. Epub 2020 May 27. PMID: 32473377 – Link
Ma ZX, Zhang RY, Rui WJ, Wang ZQ, Feng X. Quercetin alleviates chronic unpredictable mild stress-induced depressive-like behaviors by promoting adult hippocampal neurogenesis via FoxG1/CREB/ BDNF signaling pathway. Behav Brain Res. 2021 May 21;406:113245. doi: 10.1016/j.bbr.2021.113245. Epub 2021 Mar 18. PMID: 33745981 – Link
Kirste S, Treier M, Wehrle SJ, Becker G, Abdel-Tawab M, Gerbeth K, Hug MJ, Lubrich B, Grosu AL, Momm F. Boswellia serrata acts on cerebral edema in patients irradiated for brain tumors: a prospective, randomized, placebo-controlled, double-blind pilot trial. Cancer. 2011 Aug 15;117(16):3788-95. doi: 10.1002/cncr.25945. Epub 2011 Feb 1. PMID: 21287538 – Link