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Fito Colest Free

COMING SOON
Improves Cholesterol and Triglyceride levels in the blood.
PACKAGE: 30 sachets
USEFUL FOR
• digestive, liver and digestive system function • cardiovascular function • regular blood pressure • supporting the physiological metabolism of lipids (cholesterol and triglycerides)
PLUS
• vegetal formula • with botanical extracts • synergistic action • does not contain sugars • without artificial colourings and flavourings • without ingredients of animal origin • gluten-free and lactose-free • with natural excipients
HOW TO USE
We recommend taking 1 sachet dissolved in water at main meals.
WARNINGS
Do not exceed the recommended daily dose. Food supplements should not be considered a substitute for a varied, balanced diet and a healthy lifestyle. Keep out of reach of children under three years of age.
EAN: 8056046912083

The formula was created based on a synergy of substances that promote fat metabolism by improving blood cholesterol and triglyceride levels. Resveratrol is a polyphenolic compound found primarily in grapes, blueberries, raspberries, and mulberries, with multiple health benefits thanks to its anti-inflammatory, anti-tumor, and antioxidant properties. Resveratrol has been shown to protect against vascular aging by modulating the renin-angiotensin system and improving endothelial dysfunction by activating SIRT1, an important protein involved in metabolic functions, cell protection, and aging control. A meta-analysis study indicated that resveratrol supplementation could significantly influence serum levels of total cholesterol, LDL cholesterol, and triglycerides. Resveratrol supplementation has also shown several benefits in subjects with type 2 diabetes: it reduces triglyceride levels, exhibiting a more pronounced effect on LDL cholesterol reduction, mitigates insulin resistance, lowers fasting blood glucose, and improves oxidative stress. Berberine has demonstrated effects on glucose metabolism, insulin resistance, hypercholesterolemia, and even endothelial function, making it particularly useful in metabolic syndrome. In particular, berberine’s effect on blood glucose levels appears to be such that it results in a reduction in glycated hemoglobin that is comparable to that of metformin. It has demonstrated a lipid-lowering effect by increasing the expression of membrane receptors capable of internalizing LDL and reducing its levels in the blood. It has also demonstrated a cholesterol-lowering effect by inhibiting cholesterol absorption and simultaneously increasing its excretion. This mechanism (different from that of statin drugs) makes berberine a useful and effective active ingredient even for those with cholesterol resistant to statin therapy (alone or in combination). DHA ALGA Biotis® is an extract from the microalgae Schizochytrium, a rich source of unsaturated fatty acids with low iodine content. It is high in DHA (docosahexaenoic acid) and EPA (eicosapentaenoic acid), omega-3 and omega-6 fatty acids, essential for the proper functioning of our body. Its plant-based origin makes it suitable for vegans. EPA helps our body maintain normal blood pressure, healthy blood lipid levels, and supports cardiac function. DHA contributes to brain function and the maintenance of normal vision.

Coenzyme Q10 is a powerful antioxidant produced in all cells of our body and is therefore called “ubiquinone” (from the Latin ubi, “everywhere”). Numerous scientific studies have revealed the usefulness of this molecule for treating cholesterol and promoting good cardiovascular health.

The administration of coenzyme Q10 is associated with a significant improvement in arterial endothelial function, supporting the myocardial energy needs, and reducing the amount of oxidized LDL. Consequently, it counteracts the damage caused by hypertension and the formation of atherosclerotic plaque. Vitamin B6 may be helpful in cardiovascular disease because it can control and reduce blood homocysteine ​​levels, which, if elevated, can increase the risk of cardiovascular disease.

Hernández-Camacho JD. Coenzyme Q10 Supplementation in Aging and Disease. Front Physiol. 2018; 9: 44. doi: 10.3389/fphys.2018.00044 –  Link

Magno S et al. LDL-cholesterol lowering effect of a new dietary supplement: an open label, controlled, randomized, cross-over clinical trial in patients with mild-to-moderate hypercholesterolemia. Lipids Health Dis. 2018; 17: 124. doi: 10.1186/s12944-018-0775-8 – Link

Mazza A et al. Effect of Monacolin K and COQ10 supplementation in hypertensive and hypercholesterolemic subjects with metabolic syndrome. Biomed Pharmacother. 2018 Sep;105:992-996. doi: 10.1016/j.biopha.2018.06.076 – Link

Ryan M. Allen RM and Vickers KC. Coenzyme Q10 Increases Cholesterol Efflux and Inhibits Atherosclerosis through microRNAs. Arterioscler Thromb Vasc Biol. 2014 Sep; 34(9): 1795–1797.doi: 10.1161/ATVBAHA.114.303741 – Link

Saini R. Coenzyme Q10: The essential nutrient. J Pharm Bioallied Sci. 2011 Jul-Sep; 3(3): 466–467. doi: 10.4103/0975-7406.84471 – Link

Sharifi N et al. The effects of coenzyme Q10 supplementation on lipid profiles among patients with metabolic diseases: a systematic review and meta-analysis of randomized controlled trials. Curr Pharm Des. 2018 Apr 5. doi: 10.2174/1381612824666180406104516 – Link

Effect of B vitamins supplementation on cardio-metabolic factors in patients with stable coronary artery disease: A randomized double-blind trial. Asia Pac J Clin Nutr. 2020;29(2):245-25 – Link

Kong W et al. Berberine is a novel cholesterolo lowering drug working through unique mechanism distinct from statins. Nat Med 2004; 10(12):1344-1351 – Link

Yin J, Xing H, Ye J. Efficacy of berberine in patients with type 2 diabetes mellitus. Metabolism. 2008 May;57(5):712-7. doi: 10.1016/j.metabol.2008.01.013. PMID: 18442638; PMCID: PMC2410097 – Link

Affuso F, Mercurio V, Fazio V, Fazio S. Cardiovascular and metabolic effects of Berberine. World J Cardiol. 2010 Apr 26;2(4):71-7. doi: 10.4330/wjc.v2.i4.71. PMID: 21160701; PMCID: PMC2999047 – Link

Orsu P, Murthy BV, Akula A. Cerebroprotective potential of resveratrol through anti-oxidant and anti-inflammatory mechanisms in rats. J Neural Transm (Vienna). 2013 Aug;120(8):1217-23. doi: 10.1007/s00702-013-0982-4. Epub 2013 Jan 31. PMID: 23371441 – Link
Martinez J, Moreno JJ. Effect of resveratrol, a natural polyphenolic compound, on reactive oxygen species and prostaglandin production. Biochem Pharmacol. 2000 Apr 1;59(7):865-70. doi: 10.1016/s0006-2952(99)00380-9. PMID: 10718345 – Link
Gomez LS, Zancan P, Marcondes MC, Ramos-Santos L, Meyer-Fernandes JR, Sola-Penna M, Da Silva D. Resveratrol decreases breast cancer cell viability and glucose metabolism by inhibiting 6-phosphofructo-1-kinase. Biochimie. 2013 Jun;95(6):1336-43. doi: 10.1016/j.biochi.2013.02.013. Epub 2013 Feb 27. PMID: 23454376 – Link
Kim EN, Kim MY, Lim JH, Kim Y, Shin SJ, Park CW, Kim YS, Chang YS, Yoon HE, Choi BS. The protective effect of resveratrol on vascular aging by modulation of the renin-angiotensin system. Atherosclerosis. 2018 Mar;270:123-131. doi: 10.1016/j.atherosclerosis.2018.01.043. Epub 2018 Feb 2. PMID: 29407880 – Link
Jankauskas SS, Mone P, Santulli G. From resveratrol to ISIDE11: how to activate SIRT1 and improve endothelial function? New therapeutic insights for methylenetetrahydrofolate reductase deficiency. Cell Mol Life Sci. 2022 Jul 27;79(8):451. doi: 10.1007/s00018-022-04484-y. PMID: 35895130; PMCID: PMC9843588 – Link
Zhao H, Song A, Zhang Y, Shu L, Song G, Ma H. Effect of Resveratrol on Blood Lipid Levels in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis. Obesity (Silver Spring). 2019 Jan;27(1):94-102. doi: 10.1002/oby.22348. Erratum in: Obesity (Silver Spring). 2019 Feb;27(2):350. doi: 10.1002/oby.22428. PMID: 30569644 – Link
Zhang T, He Q, Liu Y, Chen Z, Hu H. Efficacy and Safety of Resveratrol Supplements on Blood Lipid and Blood Glucose Control in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Evid Based Complement Alternat Med. 2021 Aug 24;2021:5644171. doi: 10.1155/2021/5644171. PMID: 34484395; PMCID: PMC8410426 – Link
POSSIBLE ASSOCIATIONS
Melatonin, Pea, Resveralip
INGREDIENTS
Erythritol; DHA ALGA Biotis; Liposomal Resveratrol; Berberine (from Berberis Aristata DC; branch bark); CoQ10; Vitamin B6; flavoring.
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