LIPOSOMAL
The liposomal products of the NIKI NATURAL ALCHEMY line have been manufactured in compliance with the highest quality standards, using an innovative manufacturing process that gives them unique characteristics and maximum effectiveness. In particular, liposomes are microspheres capable of trapping active substances and conveying them into the body, improving their absorption and therefore effectiveness.
The main advantage of using liposomal technology is to provide nutrients and functional substances that are easily absorbed by the gastrointestinal tract and available in the body.
This line uses the strongest antioxidants found in nature and delivers them to maximize their effects.
Line Plus
• HIGH BIOAVAILABILITY
• READY-TO-USE STICK PACK
• MAXIMUM CONCENTRATION OF ACTIVE INGREDIENTS
• EASY-TO-USE SOLUBLE SACHETS
• SINGLE-DOSE SACHETS
• VEGETABLE FORMULA
• DOES NOT CONTAIN SUGARS
• WITH NATURAL EXCIPIENTS
• WITHOUT ARTIFICIAL COLOURINGS AND FLAVOURS
• WITHOUT INGREDIENTS OF ANIMAL ORIGIN
Resveratrol
Resveratrol is a naturally occurring molecule found in red grape skins, peanuts, blueberries and some other berries.
It is a powerful antioxidant produced by plants in response to stress, injury, infection or ultraviolet (UV) radiation. These antioxidant properties give it an anti-aging action by counteracting the damage caused by free radicals and allowing to fight premature aging of the body’s tissues.
Resveratrol is a powerful antioxidant capable of regulating the synthesis of antioxidant enzymes and therefore the reduction of the production of free radicals. Resveratrol is able to modulate a large number of cellular signaling pathways involved in the regulation of inflammatory processes, in the immune response to infections and stress and in the processes of tumor formation. Resveratrol is an anti-inflammatory, inhibits the proliferation of tumor cells, causes apoptosis (programmed cell death), reduces their ability to invade healthy tissues and the ability to form new blood vessels, necessary for the development of the tumor. According to recent studies, Resveratrol could act on a key molecule in the energy regulation mechanisms of the cell, leading to the conversion of white adipose tissue into brown adipose tissue, with consequent reduction in body weight of treated animals.
Numerous studies have shown the ability of Resveratrol to increase the expression of Angiotensin 1-7 through the suppression of the ANG II/AT1R axis, through the enhancement of the Ang (1-7)/Mas axis and through the increase in plasma levels of the same Angiotensin 1-7. Resveratrol therefore acts, with its protective effect and its ability to counteract aging, on the Cardiovascular System and the Renal System, improving their functionality.
Resveratrol can inhibit some processes that lead to the development of cardiovascular diseases, protects vessels from plaque formation and the proliferation of smooth muscle tissue, stimulates the production of nitric oxide responsible for vasodilation processes and inhibits platelet activation and aggregation, the first step in the formation of clots that can cause heart attacks and strokes. Resveratrol has a protective action against neurodegenerative diseases. It stimulates neurogenesis and the formation of new vessels in the brain, stimulates the removal of the β-amyloid peptide, a constituent of the amyloid plaque, which accumulates in certain areas of the brain in subjects affected by Alzheimer’s disease, and reduces inflammatory processes and oxidative stress at the level of neurons.
Finally, some studies have demonstrated the importance of using Resveratrol as a chemoprotective, useful in resistance to chemotherapy. Some studies have shown that Resveratrol has reduced cardiac toxicity from Doxorubicin, decreasing cardiovascular risk, eliminating reactive oxygen species (ROS) and protecting tissues. In addition, Resveratrol has shown in some studies an increase in antitumor efficacy and has reduced the cardiotoxic and nephrotoxic effect of arsenic trioxide in hematological malignancies, activating antioxidant defense mechanisms.
Quercetin
Quercetin is found in foods but is found exclusively in plant-based foods. The richest food sources are: capers, tomatoes, broccoli, asparagus, onions, apples, grapes, coffee.
The typical characteristic of Quercetin is the presence, in its chemical structure, of different phenolic groups that allow the compound to function as a powerful antioxidant through different mechanisms of action: it neutralizes free radicals and increases the production of antioxidant enzymes by the body.
Many in vivo and in vitro studies have shown that Quercetin also has powerful anti-inflammatory and immunostimulant properties: it inhibits the resulting inflammatory cascade, inhibits the production of enzymes that produce inflammation: cyclooxygenase (COX) and lipoxygenase (LOX), inhibits the release of pro-inflammatory cytokines, inhibits the production of inflammation mediators. Thanks to its antioxidant and anti-inflammatory properties, Quercetin exerts several biological effects: it prevents myocardial cell damage and protects the heart from cardiac dysfunction, prevents neurodegenerative diseases but also anxiety and depression, reduces the toxicity of some pharmacological and non-pharmacological agents (for example Cyclophosphamide, Cisplatin, Ciprofloxacin, Manganese, Cadmium, Arsenic), improves idiopathic pulmonary fibrosis and acute lung damage, prevents type II diabetes, improves osteoarthritis.
Studies have also demonstrated anti-cancer effects of Quercetin which are based on its ability to reduce cell proliferation and induce apoptosis of cancer cells. Quercetin is able to enhance the effect of anti-cancer therapies, both chemo and radiotherapy, making tumor cells more sensitive and protecting healthy cells. This effect has been observed especially in case of therapy with Irinotecan, Fludarabine, Platinum, Doxorubicin, Cyclophosphamide, Docetaxel. The main forms of cancer on which antitumor effects of Quercetin have been observed are: ovarian cancer, leukemia, lymphoma, breast cancer, prostate cancer, osteosarcoma, melanoma, lung cancer and colorectal cancer.
Generally taken at low concentrations, it works as an antioxidant protecting cells from damage by radicals (cancer-protective effect), while at high concentrations it works as a pro-oxidant with consequent cytotoxicity at the level of tumor cells.
Quercetin is poorly bioavailable due to reduced absorption at intestinal level (varies from 17 to 50%), and rapid metabolism and excretion. All this leads to a short half-life of Quercetin metabolites in the blood. The effectiveness of Quercetin can be improved by transporting it in liposomes that facilitate its absorption.
Curcumin
Turmeric is a spice with countless beneficial properties that have been attributed in particular to Curcumin as an active substance.
Curcumin is a powerful antioxidant capable of activating various enzymes and enhancing the physiological antioxidant system and is therefore very useful in the prevention and treatment of diseases characterized by oxidative stress (aging, diabetes, cardiovascular diseases, neurodegenerative diseases, cancer).
Unlike many other antioxidants, Curcumin has a dual activity as it is able to both prevent the formation of free radicals and neutralize existing free radicals.
Curcumin is a powerful anti-inflammatory and is very useful in the prevention and treatment of inflammatory diseases, especially at the gastrointestinal level, improves the functionality of the stomach and intestine, is useful in disorders such as colitis, pancreatitis, neurodegenerative diseases, cardiovascular diseases, autoimmune diseases, inflammatory bowel diseases (Crohn’s disease), obesity, diabetes, respiratory diseases such as asthma and bronchitis, psoriasis and cancer. According to a recent study, Curcumin in the body is transformed into a substance with neuroprotective capacity capable of reducing oxidative stress and neuroinflammation, improving neurological function. It can also prevent neurodegeneration typical of Parkinson’s disease and can be useful in Alzheimer’s disease as it maintains normal structure and function of cerebral vessels and synapses.
Curcumin, after oral ingestion, can exert regulatory effects on the intestinal microbiota, helping to improve well-being and problems related to alterations of this balance.
Curcumin supplementation can also be useful in the treatment of type 2 diabetes mellitus: a 2019 study showed that treating diabetic mice with Curcumin resulted in improved insulin sensitivity, reduced blood sugar levels, and improved dyslipidemia.
Curcumin is very effective in the treatment of cardiovascular diseases through several mechanisms: reduction of plasma lipids, increase in HDL levels, reduction of lipid peroxidation, reduction of atherosclerotic lesions, and improvement of endothelial function. There is evidence in the literature of the effectiveness of Curcumin especially in the treatment of the following types of tumors: Breast cancer, Lung cancer, Hematological and lymphatic system tumors, Stomach cancer, Oral cavity cancer, Colorectal cancer, Pancreatic cancer, Liver cancer, Prostate cancer, Brain tumors, Mesothelioma, Fibrosarcoma, and Melanoma. Various studies have shown that Curcumin is also an excellent aid to counteract the typical side effects of chemotherapy such as gastrointestinal toxicity, cardiotoxicity and hepatotoxicity.
Despite all the benefits it brings to health and the numerous properties of Turmeric, one of the main critical issues of Curcumin is its poor bioavailability.
The liposomal solution allows maximum absorption. The liposome formulation also allows you to avoid all those products that contain “piperine”, a highly inflammatory and irritating substance, not recommended for those suffering from gastric disorders or for cancer patients.
Discover the products
-
Curcuminlip
24,90 € -
Resveralip
29,90 € -
Quercilip
32,90 €
NOTE: Supplements are not intended as a substitute for a varied and balanced diet and a healthy lifestyle. Do not exceed the recommended daily doses. The information in the product sheets should not be interpreted as medical advice and is not intended to and cannot replace medical prescriptions. The information provided is for informational and educational purposes only and concerns the ingredients contained in food supplements. Supplements are not intended as a means of treating, preventing, diagnosing or alleviating pathologies.
Curcumina
Int J Mol Sci.2020 Feb 7. Evaluation of Antioxidant Activity of Spice-Derived Phytochemicals Using Zebrafish. Endo Y, Muraki K, Fuse Y, Kobayashi M. – Link
Eur Cardiol.2019 Jul 11. Anti-inflammatory Action of Curcumin and Its Use in the Treatment of Lifestyle-related Diseases. Shimizu K, Funamoto M, Sunagawa Y, Shimizu S, Katanasaka Y, Miyazaki Y, Wada H, Hasegawa K, Morimoto T. – Link
Nutrients. 2019 Oct. Curcumin, Gut Microbiota, and Neuroprotection. Francesco Di Meo,Sabrina Margarucci, Umberto Galderisi, Stefania Crispi, and Gianfranco Peluso – Link
Food Nutr Res. 2017. Regulative effects of curcumin spice administration on gut microbiota and its pharmacological implications. Liang Shen,Lu Liu, and Hong-Fang Ji – Link
Nutrients. 2019 Aug. Curcumin and Type 2 Diabetes Mellitus: Prevention and Treatment. Francesca Pivari,Alessandra Mingione, Caterina Brasacchio, and Laura Soldati – Link
Nutrients. 2013 Oct. Polyphenols: Benefits to the Cardiovascular System in Health and in Aging. Sandhya Khurana,Krishnan Venkataraman, Amanda Hollingsworth, Matthew Piche, and C. Tai – Link
Drug Des Devel Ther.2018 Dec 3. Curcumin alleviates rheumatoid arthritis-induced inflammation and synovial hyperplasia by targeting mTOR pathway in rats. Dai Q, Zhou , Xu L, Song X – Link
Med Sci (Basel). 2017 Dec. Regulation of Polyamine Metabolism by Curcumin for Cancer Prevention and Therapy. Tracy Murray-Stewartand Robert A. Casero, Jr. Nutrients. 2019 Oct 5. Curcumin and Cancer. Giordano A, Tommonaro G. – Link
Front Pharmacol. 2018. Preventive Effect of Curcumin Against Chemotherapy-Induced Side-Effects. Zhijun Liu,Pengyun Huang,Siukan Law, Haiyan Tian, Wingnang Leung, and Chuanshan Xu – Link
Cancer Res Treat. 2014 Jan 15. Recent Developments in Delivery, Bioavailability, Absorption and Metabolism of Curcumin: the Golden Pigment from Golden Spice. Sahdeo Prasad, PhD, Amit K. Tyagi, PhD, and Bharat B. Aggarwal, PhD – Link
Int J Nanomedicine.2019 Dec 10. Evaluation of Intestinal Absorption Mechanism and Pharmacokinetics of Curcumin-Loaded Galactosylated Albumin Nanoparticles.Huang Y, Deng S, Luo X, Liu Y, Xu W, Pan J, Wang M, Xia Z – Link
\Int J Nanomedicine.2017 Aug 21. Liposomal curcumin and its application in cancer. Feng T, Wei Y, Lee RJ, Zhao L. – Link
Adeeb Shehzad , Jeen-Woo Park, Jaetae Lee, Young Sup Lee “Curcumin induces radiosensitivity of in vitro and in vivo cancer models by modulating pre-mRNA processing factor 4 (Prp4)” PubMed, 2013 – Link
Amir Abbas Momtazi-Borojeni Faezeh Ghasemi Amirreza Hesari , Muhammed Majeed Michele Caraglia , Amirhossein Sahebkar “Anti-Cancer and Radio-Sensitizing Effects of Curcumin in Nasopharyngeal Carcinoma” PubMed, 2018 – Link
G Bar-Sela , R Epelbaum, M Schaffer “Curcumin as an anti-cancer agent: review of the gap between basic and clinical applications” PubMed, 2010 – Link
Guangen Yang 1, Jianming Qiu 2, Dong Wang 1, Yong Tao 3, Yihuan Song 1, Hongtao Wang 1, Juping Tang 1, Xing Wang 4, Y U Sun 5, Zhijian Yang 5 6, Robert M Hoffman 6 7 “Traditional Chinese Medicine Curcumin Sensitizes Human Colon Cancer to Radiation by Altering the Expression of DNA Repair-related Genes” PubMed, 2018 – Link
Kevin Doello , Raúl Ortiz , Pablo J Alvarez , Consolación Melguizo , Laura Cabeza , José Prados “Latest in Vitro and in Vivo Assay, Clinical Trials and Patents in Cancer Treatment using Curcumin: A Literature Review” PubMed, 2018 – Link
Moshe Schaffer , Pamela M Schaffer, Jamal Zidan, Gil Sela “Curcuma as a functional food in the control of cancer and inflammation” PubMed, 2011 – Link
Rajesh Kumar Kesharwani , Vandana Srivastava, Prabhakar Singh, Syed Ibrahim Rizvi, Kuruba Adeppa, Krishna Misra “A Novel Approach for Overcoming Drug Resistance in Breast Cancer Chemotherapy by Targeting new Synthetic Curcumin Analogues Against Aldehyde Dehydrogenase 1 (ALDH1A1) and Glycogen Synthase Kinase-3 ß (GSK-3ß)” PubMed, 2015 – Link
Resveratrolo
Oncotarget. 2017 Aug 9. A comparative study of anti-aging properties and mechanism: resveratrol and caloric restriction. Li J, Zhang CX, Liu YM, Chen KL, Chen G. – Link
J Cosmet Laser Ther. 2019. Resveratrol as an active ingredient for cosmetic and dermatological applications: a review. Ratz-Łyko A, Arct J. – Link
Nutrients. 2019 May. Influence of Resveratrol on the Immune Response. Lucia Malaguarnera – Link
Antioxidants (Basel). 2018 Oct 20. Cytoprotective Effects of Natural Compounds against Oxidative Stress. Mehta J, Rayalam S, Wang X. – Link
Int J Clin Exp Pathol. 2014 Oct 15. Cardioprotective effect of resveratrol on atherogenic diet-fed rats. Meng C, Liu JL, Du AL. – Link
Aleksandra Rodacka, Joanna Strumillo, Mieczyslaw Puchala, Eligiusz Serafin, Grzegorz Bartosz “Comparison of protective properties of resveratrol and melatonin in the radiation inactivation and destruction of glyceraldehyde-3-phosphate dehydrogenase and lactate dehydrogenase” PubMed 2019 – Link
Amini, Saeedeh Jafari Nodooshan, Milad Ashrafizadeh, Seyed-Mohammad Eftekhari, Tayebeh Aryafar, Leila Khalafi, Ahmed Eleojo Musa, Seyed Rabie Mahdavi, Masoud Najafi, Bagher Farhood “Resveratrol Induces Apoptosis and Attenuates Proliferation of MCF-7 Cells in Combination with Radiation and Hyperthermia” PubMed, 2021 – Link
Endocr Relat Cancer. 2014 May 6. Resveratrol and cancer: focus on in vivo evidence. Carter LG, D’Orazio JA, Pearson KJ. – Link
Oncol Lett. 2020 Apr. Autophagy suppresses resveratrol-induced apoptosis in renal cell carcinoma 786-O cells. Yao H, Fan M, He X. – Link
Oncotarget. 2017 Mar 7. Resveratrol induces cell cycle arrest and apoptosis with docetaxel in prostate cancer cells via a p53/ p21WAF1/CIP1 and p27KIP1 pathway. Singh SK, Banerjee S, Acosta EP, Lillard JW, Singh R. – Link
Effects of resveratrol on human immune cell function. Falchetti R, Fuggetta MP, Lanzilli G, Tricarico M, Ravagnan G. Life Sci. 2001 Nov 21;70(1):81-96 – Link
In vitro antitumour activity of resveratrol in human melanoma cells sensitive or resistant to temozolomide. Fuggetta MP, D’Atri S, Lanzilli G, Tricarico M, Cannavò E, Zambruno G, Falchetti R, Ravagnan G. Melanoma Res. 2004 Jun;14(3):189-96 – Link
Effect of resveratrol on proliferation and telomerase activity of human colon cancer cells in vitro. Fuggetta MP, Lanzilli G, Tricarico M, Cottarelli A, Falchetti R, Ravagnan G, Bonmassar E. J Exp Clin Cancer Res. 2006 Jun;25(2):189-93 – Link
Resveratrol down-regulates the growth and telomerase activity of breast cancer cells in vitro. Lanzilli G, Fuggetta MP, Tricarico M, Cottarelli A, Serafino A, Falchetti R, Ravagnan G, Turriziani M, Adamo R, Franzese O, Bonmassar E. Int J Oncol. 2006 Mar;28(3):641-8 – Link
Int J Mol Sci. 2019 Feb 20. Resveratrol as a Tumor-Suppressive Nutraceutical Modulating Tumor Microenvironment and Malignant Behaviors of Cancer. Han Y1,2, Jo H3,4, Cho JH5, Dhanasekaran DN6, Song YS7,8,9 – Link
Molecules. 2019 Mar 21. Resveratrol Inhibits the Migration and Metastasis of MDA-MB- 231 Human Breast Cancer by Reversing TGF-β1-Induced Epithelial-Mesenchymal Transition. Sun Y, Zhou QM, Lu YY, Zhang H, Chen QL, Zhao M, Su SB – Link
Cancer Med. 2019 Mar. Resveratrol promotes sensitization to Doxorubicin by inhibiting epithelial-mesenchymal transition and modulating SIRT1/β-catenin signaling pathway in breast cancer. Jin X, Wei Y, Liu Y, Lu X, Ding F, Wang J, Yang S. – Link
Phytomedicine. 2019 Mar 1. Resveratrol mediated cancer cell apoptosis, and modulation of multidrug resistance proteins and metabolic enzymes. El-Readi MZ, Eid S, Abdelghany AA, Al-Amoudi HS, Efferth T, Wink MInt J Mol Sci. 2020 Mar 18. Potential Adverse Effects of Resveratrol: A Literature Review. Shaito A, Posadino AM, Younes N, Hasan H, Halabi S, Alhababi D, Al-Mohannadi A, Abdel-Rahman WM, Eid AH, Nasrallah G, Pintus G – Link
Dan-Dan Zhou 1, Min Luo 1, Si-Yu Huang 1, Adila Saimaiti 1, Ao Shang 1, Ren-You Gan 2 3, Hua-Bin Li 1 “Effects and Mechanisms of Resveratrol on Aging and Age-Related Diseases” PubMed 2021 – Link
Giulia Lanzilli, Andrea Cottarelli, Giuseppe Nicotera, Serena Guida, Giampiero Ravagnan, Maria Pia FuggettaAnti-inflammatory effect of resveratrol and polydatin by in vitro IL-17 modulation PuBMed, 2012 – Link
Prem Kumar, Anupam Bishayee, Kwang Seok Ahn “The Role of Resveratrol in Cancer Therapy” PubMed 2017 – Link
Samaneh Brenjian , Ashraf Moini , Nazila Yamini , Ladan Kashani , Maryam Faridmojtahedi, Mojdeh Bahramrezaie , Mahshad Khodarahmian , Fardin Amidi “Resveratrol treatment in patients with polycystic ovary syndrome decreased pro-inflammatory and endoplasmic reticulum stress markers” PubMed 2020 – Link
Seyed Hossein Shahcheraghi , Mahtab Zangui , Marzieh Lotfi , Majid Ghayour-Mobarhan , Ahmad Ghorbani , Hossein Zarei Jaliani , Hamid Reza Sadeghnia , Amirhossein Sahebkar ”Therapeutic Potential of Curcumin in the Treatment of Glioblastoma Multiforme” PubMed, 2019 – Link
Shannon Reagan-Shaw, Hasan Mukhtar, Nihal Ahmad “Resveratrol imparts photoprotection of normal cells and enhances the efficacy of radiation therapy in cancer cells” PubMed 2008 – Link
Shi-Jun Wang 1, Xing-Xiang Wang, Fang-Hua Fan “Inhibitory effect of resveratrol on cardiac fibroblast proliferation induced by angiotensin II” PubMed 2008
Soltan 1, Mansour Esmaili Dahej 1, Maryam Yadegari 2, Ali Moradi 3, Zeinab Hafizi Barjin 1, Fatemeh Safari 1 4 Resveratrol Confers Protection Against Ischemia/Reperfusion Injury by Increase of Angiotensin (1-7) Expression in a Rat Model of Myocardial Hypertrophy” PubMed 2021 – Link
Quercitina
Oxid Med Cell Longev. 2016. Mechanisms of Neuroprotection by Quercetin: Counteracting Oxidative Stress and More. Costa LG, Garrick JM, Roquè PJ, Pellacani C. – Link
Molecules. 2019 Mar 21. Antioxidant Activities of Quercetin and Its Complexes for Medicinal Application. Xu D, Hu MJ, Wang YQ, Cui YL. – Link
Nutrients. 2016 Mar 15. Quercetin, Inflammation and Immunity. Li Y, Yao J, Han C, Yang J, Chaudhry MT, Wang S, Liu H, Yin Y. – Link
Ok-Joo Sul , Seung Won Ra “Quercetin Prevents LPS-Induced Oxidative Stress and Inflammation by Modulating NOX2/ROS/NF-kB in Lung Epithelial Cells” PubMed 2021 – Link
Yan Yang, Xu Zhang, Min Xu, Xin Wu, Feipeng Zhao, Chengzhi Zhao: “Quercetin attenuates collagen-induced arthritis by restoration of Th17/Treg balance and activation of Heme Oxygenase 1-mediated anti-inflammatory effect” PubMed 2018 – Link
Molecules. 2017 Jan 29. Actions of Quercetin, a Polyphenol, on Blood Pressure. Marunaka Y, Marunaka R, Sun H, Yamamoto T, Kanamura N, Inui T, Taruno A. – Link
Nutr Rev. 2010 Jul. Hormesis and synergy: pathways and mechanisms of quercetin in cancer prevention and management. Vargas AJ, Burd R. – Link
International Journal of Molecular Sciences. The Anti-Cancer E ect of Quercetin: Molecular Implications in Cancer Metabolism. Marjorie Reyes-Farias, Catalina Carrasco-Pozo – Link
Biomolecules. 2019 May 6. Fisetin and Quercetin: Promising Flavonoids with Chemopreventive Potential. Kashyap D, Garg VK, Tuli HS, Yerer MB, Sak K, Sharma AK, Kumar M, Aggarwal V, Sandhu SS. – Link
Nutrients. 2019 Sep 25. Dietary Quercetin and Kaempferol: Bioavailability and Potential Cardiovascular-Related Bioactivity in Humans. Dabeek WM, Marra MV. – Link
Mol Nutr Food Res. 2018 Jan. Safety Aspects of the Use of Quercetin as a Dietary Supplement. Andres S, Pevny S, Ziegenhagen R, Bakhiya N, Schäfer B, Hirsch-Ernst KI, Lampen A. – Link